Pyridine nucleotides in erythrocyte metabolism.
نویسندگان
چکیده
منابع مشابه
Pyridine Nucleotides in Erythrocyte Metabolism * RUTH
In recent years investigations of erythrocyte metabolism have been concerned with the interrelationships of enzymes, coenzymes, substrates, cofactors, and pH, inter alia (1-8). Although data have accumulated on these various aspects of the metabolism of normal and pathological erythrocytes, little direct information has been available heretofore on pyridine nucleotide coenzymes, despite their i...
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The experiments described previously (Birt & Bartley, 1960a, b) have shown that the amounts and state of reduction of the endogenous pyridine nucleotides of rat-liver mitochondria are controlled by the components of the incubating medium. This paper is concerned with a general study of the effects of the temperature of incubation, the addition of various substrates, 2:4-dinitrophenol and amytal...
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The pyridine nucleotides NAD and NADP play a pivotal role in regulating intermediary metabolism in the heart. The intracellular NAD /NADH ratio controls flux through various dehydrogenase enzymes involved in both anaerobic and aerobic metabolism and also regulates posttranslational protein modification. The intracellular NADP /NADPH ratio controls flux through the pentose phosphate pathway (PPP...
متن کاملDecreased erythrocyte nicotinamide adenine dinucleotide redox potential and abnormal pyridine nucleotide content in sickle cell disease.
RBCs from individuals with sickle cell disease are more susceptible to oxidant damage. Because key antioxidant defense reactions are linked to the pyridine nucleotides nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), we tested the hypothesis that the RBC redox potential as manifested by the NADH/[NAD+ + NADH] and NADPH/[NADP+ + NADPH] ratios is dec...
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 45 2 شماره
صفحات -
تاریخ انتشار 1966